Dataset Information

Whole proteome analysis of mesonephric-derived cancers describes new potential biomarkers

ABSTRACT: Mesonephric carcinomas (ME) and Female Adnexal Tumors of probable Wolffian Origin (FATWO) are thought to derive from remnants of the Wolffian/mesonephric ducts – anlages of the male reproductive tract. Mesonephric-like carcinomas (MLC) show identical morphology to ME of the cervix, but occur in the uterus and ovary without convincing mesonephric remnants. ME, MLC and FATWO are challenging to diagnose due to their morphologic similarities to Müllerian tumors, resulting in a lack of evidence-based and tumor-specific treatment regimens. In order to identify potential diagnostic biomarkers, we performed whole proteomic analysis on 9 ME/MLC and 56 endometrial carcinomas (EC). ME and MLC proteomes showed significant overlap with few distinguishing protein markers.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Uterine Endometrium, Mesonephric Duct

DISEASE(S): Wolffian Duct Adenocarcinoma

SUBMITTER: Gian Luca Negri

LAB HEAD: Gregg Morin

PROVIDER: PXD020879 | Pride | 2020-11-02

REPOSITORIES: Pride

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Whole-proteome analysis of mesonephric-derived cancers describes new potential biomarkers.

Gibbard Evan E Cochrane Dawn R DR Pors Jennifer J Negri Gian Luca GL Colborne Shane S Cheng Angela S AS Chow Christine C Farnell David D Tessier-Cloutier Basile B McAlpine Jessica N JN Morin Gregg B GB Schmidt Dietmar D Kommoss Stefan S Kommoss Friedrich F Keul Jacqueline J Gilks Blake B Huntsman David G DG Hoang Lynn L

Human pathology 20201026

Mesonephric carcinomas (MEs) and female adnexal tumors of probable Wolffian origin (FATWO) are derived from embryologic remnants of Wolffian/mesonephric ducts. Mesonephric-like carcinomas (MLCs) show identical morphology to ME of the cervix but occur in the uterus and ovary without convincing mesonephric remnants. ME, MLC, and FATWO are challenging to diagnose due to their morphologic similarities to Müllerian/paramesonephric tumors, contributing to a lack of evidence-based and tumor-specific tr ...[more]

PMID: 33121982

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