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An Integrative Omics Approach Reveals Involvement of BRCA1 in Hepatic Metastatic Progression of Colorectal Cancer

ABSTRACT: The role of different cells in the tumor microenvironment (TME) is critical to the metastatic process. Phenotypic transformation of the liver cells is one of the most important stages of hepatic metastasis progression of colorectal cancer (CRC). Our aim was to identify the major molecules (i.e. genes, miRNAs and proteins) involved in this process.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kupffer Cell, Hepatic Stellate Cell, Liver, Endothelial Cell Of Hepatic Sinusoid

DISEASE(S): Liver Cancer

SUBMITTER: Gereon Poschmann

LAB HEAD: Gereon Poschmann

PROVIDER: PXD020913 | Pride | 2020-08-27

REPOSITORIES: Pride

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An Integrative Omics Approach Reveals Involvement of <i>BRCA1</i> in Hepatic Metastatic Progression of Colorectal Cancer.

Gerovska Daniela D Larrinaga Gorka G Solano-Iturri Jon Danel JD Márquez Joana J García Gallastegi Patricia P Khatib Abdel-Majid AM Poschmann Gereon G Stühler Kai K Armesto María M Lawrie Charles H CH Badiola Iker I Araúzo-Bravo Marcos J MJ

Cancers 20200822 9

(1) Background & Aims: The roles of different cells in the tumor microenvironment (TME) are critical to the metastatic process. The phenotypic transformation of the liver cells is one of the most important stages of the hepatic metastasis progression of colorectal cancer (CRC). Our aim was to identify the major molecules (i.e., genes, miRNAs and proteins) involved in this process. (2) Methods: We isolated and performed whole-genome analysis of gene, miRNA, and protein expression in three types o ...[more]

PMID: 32842712

Publication: 1/2

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