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Development of a comprehensive toxicity pathway model for 17α-ethinylestradiol in early life stage fathead minnows (Pimephales promelas)

ABSTRACT: The goal of this study is to characterize molecular toxicity pathways associated with ethinylestradiol-induced toxicity and link these molecular perturbations to apical outcomes of regulatory relevance.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Pimephales Promelas

TISSUE(S): Whole Body

SUBMITTER: Alper James Alcaraz

LAB HEAD: Markus Hecker

PROVIDER: PXD021155 | Pride | 2021-04-09

REPOSITORIES: Pride

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			Action	DRS
	3254_Lumik1_150IS_HCD-OT_HA_1.raw	Raw
	3254_Lumik1_150IS_HCD-OT_HB_1.raw	Raw
	3254_Lumik1_150IS_HCD-OT_HC_1.raw	Raw
	3254_Lumik1_150IS_HCD-OT_HD_1.raw	Raw
	3254_Lumik1_150IS_HCD-OT_HE_1.raw	Raw

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Publications

Development of a Comprehensive Toxicity Pathway Model for 17α-Ethinylestradiol in Early Life Stage Fathead Minnows (Pimephales promelas).

Alcaraz Alper James G AJG Potěšil David D Mikulášek Kamil K Green Derek D Park Bradley B Burbridge Connor C Bluhm Kerstin K Soufan Othman O Lane Taylor T Pipal Marek M Brinkmann Markus M Xia Jianguo J Zdráhal Zbyněk Z Schneider David D Crump Doug D Basu Niladri N Hogan Natacha N Hecker Markus M

Environmental science & technology 20210323 8

There is increasing pressure to develop alternative ecotoxicological risk assessment approaches that do not rely on expensive, time-consuming, and ethically questionable live animal testing. This study aimed to develop a comprehensive early life stage toxicity pathway model for the exposure of fish to estrogenic chemicals that is rooted in mechanistic toxicology. Embryo-larval fathead minnows (FHM; Pimephales promelas) were exposed to graded concentrations of 17α-ethinylestradiol (water c ...[more]

PMID: 33755441

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