Dataset Information

Quantitative TMT proteomics of brainstem in spontaneously hypertensive rats

ABSTRACT: The brainstem, the core of the central nervous system, plays a vital role in controlling arterial blood pressure and its elevation of hypertension subtypes, especially essential hypertension. Integrative metabolic and proteomic profiling was performed on the brainstem samples of 11-week-old spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar rats, using hydrophilic interaction liquid chromatography-quadrupole/time-of-flight mass spectrometry (HILIC-Q/TOFMS) and nano-liquid chromatography-high-resolution-mass spectrometry (nano-LC-high-resolution-MS) combined with quantitative tandem mass tags (TMT).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Cheng Yu

LAB HEAD: Yu Cheng

PROVIDER: PXD021210 | Pride | 2020-09-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Brainstem-SHR-Resultwithidentification.xlsx	Xlsx
	Sampledescription-Proteomicprofilinganalysis.xlsx	Xlsx
	YZL_IPIrat_result.sf3	Other
	YZLfirst01.raw	Raw
	YZLfirst02.raw	Raw

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Publications

Integrative Metabolic and Proteomic Profiling of the Brainstem in Spontaneously Hypertensive Rats.

Cheng Yu Y Sun Dongmei D Zhu Bangjie B Zhou Wenbin W Lv Chunming C Kou Fang F Wei Hai H

Journal of proteome research 20200915 10

The brainstem, the core of the central nervous system, plays a vital role in controlling arterial blood pressure and its elevation of hypertension subtypes, especially essential hypertension. Integrative metabolic and proteomic profiling was performed on the brainstem samples of 11 week old spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar rats, using hydrophilic interaction liquid chromatography quadrupole/time-of-flight mass spectrometry (HILIC-Q/TOFMS) (PeptideAtlas: ...[more]

PMID: 32869641

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