Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Embryonic Kidney Cell Line
SUBMITTER: Richard Imre
LAB HEAD: Fumiyo Ikeda
PROVIDER: PXD021217 | Pride | 2020-08-31
REPOSITORIES: Pride
Items per page: 1 - 5 of 40 |
The EMBO journal 20201120 24
HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), is a critical regulator of inflammation. However, how HOIP itself is regulated to control inflammatory responses is unclear. Here, we discover that site-specific ubiquitination of K784 within human HOIP promotes tumor necrosis factor (TNF)-induced inflammatory signaling. A HOIP K784R mutant is catalytically active but shows reduced induction of an NF-κB reporter relative to wild-type HOIP. HOIP K784 is evolutio ...[more]