Proteomics

Dataset Information

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Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants


ABSTRACT: Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neuronal Stem Cell

DISEASE(S): Brain Glioma

SUBMITTER: Jimi Wills  

LAB HEAD: Steven M Pollard

PROVIDER: PXD021270 | Pride | 2021-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
02_CTL-1.raw Raw
03_CTL-2.raw Raw
04_CTL-3.raw Raw
05_P2D3-G34R-1.raw Raw
06_P2D3-G34R-2.raw Raw
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Publications


Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K27M preferentially within the hindbrain. The reasons for this contrasting etiology are unknown. By engineering human fetal neural stem cell cultures from distinct brain regions, we demonstrate here that cell-intrinsic regional identity provides differ  ...[more]

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