Dataset Information
ARH3-regulated cytokine signaling in MIN6 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Min6-n8 Cell
DISEASE(S): Type 1 Diabetes Mellitus
SUBMITTER: 
Ernesto Nakayasu
LAB HEAD: Ernesto Nakayasu
PROVIDER: PXD021501 | Pride | 2024-05-21
REPOSITORIES: pride
Dataset's files
Items per page: 1 - 5 of 15 |
Publications
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis.
Cell communication and signaling : CCS 20240221 1
<h4>Background</h4>Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death.<h4>Methods</h4>We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabetic non-obese mice. We also perfo ...[more]
