Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: Julia Marchingo
LAB HEAD: Gillian M. Griffiths
PROVIDER: PXD021508 | Pride | 2022-06-09
REPOSITORIES: Pride
Items per page: 1 - 5 of 32 |
Science (New York, N.Y.) 20211015 6565
T cell receptor activation of naïve CD8<sup>+</sup> T lymphocytes initiates their maturation into effector cytotoxic T lymphocytes (CTLs), which can kill cancer and virally infected cells. Although CTLs show an increased reliance on glycolysis upon acquisition of effector function, we found an essential requirement for mitochondria in target cell–killing. Acute mitochondrial depletion in USP30 (ubiquitin carboxyl-terminal hydrolase 30)–deficient CTLs markedly diminished killing capacity, althoug ...[more]