Proteomics

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Ciprofloxacin-resistant Staphylococcus aureus keeps resistance and virulence in Iron-restricted Condition

ABSTRACT: In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed that CIP-R saves the energy by storing the glucose and increases the cell wall synthesis. Moreover, CIP-R more stable in many metabolisms than CIP-S due to the up-regulation them during long term pressure of antibiotics, which could keep the survival ability of CIP-R. These advantages not possessed by CIP-S, makes the CIP-R easier to reside in host and keep resistance ability. Importantly, CIP-R exhibited an increased virulence under iron limitation condition which is completely different from sensitive bacteria. The novel adapting countermeasures reveal the reason why the CIP-R were harder to eliminate by human immunity system and help people to find out a new method for the CIP-R treatment.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Staphylococcus Aureus

TISSUE(S): Bacterial Protein, Whole Body

SUBMITTER: YingShan DONG  

LAB HEAD: Xuesong SUN

PROVIDER: PXD021692 | Pride | 2021-03-31

REPOSITORIES: Pride

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Source:
Action DRS
20171201_MXY_DDA_1.msf Msf
DDA_1.raw Raw
DDA_2.raw Raw
DDA_3.raw Raw
DIA_CIP-R1.raw Raw
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Publications

Ciprofloxacin-Resistant <i>Staphylococcus aureus</i> Displays Enhanced Resistance and Virulence in Iron-Restricted Conditions.

Dong Yingshan Y   Miao Xinyu X   Zheng Yun-Dan YD   Liu Jiajia J   He Qing-Yu QY   Ge Ruiguang R   Sun Xuesong X  

Journal of proteome research 20210419 5

The unreasonable misuse of antibiotics has led to the emergence of large-scale drug-resistant bacteria, seriously threatening human health. Compared with drug-sensitive bacteria, resistant bacteria are difficult to clear by host immunity. To fully explore the adaptive mechanism of resistant bacteria to the iron-restricted environment, we performed data-independent acquisition-based quantitative proteomics on ciprofloxacin (CIP)-resistant (CIP-R) <i>Staphylococcus aureus</i> in the presence or ab  ...[more]

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