Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart, Liver
SUBMITTER: Irina Kuznetsova
LAB HEAD: Aleksandra Filipovska
PROVIDER: PXD021762 | Pride | 2021-09-09
REPOSITORIES: Pride
Action | DRS | |||
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S12_EP444_liver_NCD_30w.raw | Raw | |||
S12_EP455_liver_NCD_30w.raw | Raw | |||
S12_EP490_Heart_NCD_30w.raw | Raw | |||
S12_EP510_Heart_NCD_30w.raw | Raw | |||
S12_EP511_Heart_NCD_30w.raw | Raw |
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Aging cell 20210607 7
Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error-prone (Mrps12<sup>ep</sup><sup>/</sup><sup>ep</sup> ) or hyper-accurate (Mrps12<sup>ha</sup><sup>/</sup><sup>ha</sup> ) mitochondrial ribosomes. Intriguingly, although both mutations are metabolically beneficial in ...[more]