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LC-MSMS analysis of apple canker pathogen Valsa mali

ABSTRACT: In order to explore the role of LaeA in secondary metabolite biosynthetic gene clusters’ regulation, toxin production, and virulence of Valsa mali, TMT-based proteomic analysis of wildtype, LaeA deletion mutant and overexpression mutant were performed. Totally, 4,299 proteins (FDR < 0.01) were identified by searching against the Valsa mali protein sequence database.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Valsa Mali

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Sheng Zhang

LAB HEAD: Sheng Zhang

PROVIDER: PXD021783 | Pride | 2021-09-09

REPOSITORIES: Pride

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			Action	DRS
	Feng2015_TMT10Plex_12Frs_Merged.mgf	Mgf
	Feng2015_TMT10Plex_12Frs_Merged.msf	Msf
	Feng2015_TMT10Plex_Fr_1.raw	Raw
	Feng2015_TMT10Plex_Fr_10.raw	Raw
	Feng2015_TMT10Plex_Fr_11.raw	Raw

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Publications

LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.

Feng Yaqiong Y Yin Zhiyuan Z Wu Yuxing Y Xu Liangsheng L Du Hongxia H Wang Nana N Huang Lili L

Frontiers in microbiology 20201105

Apple Valsa canker is a destructive disease caused by the ascomycete Valsa mali and poses a serious threat to apple production. Toxins synthesized by secondary metabolite biosynthetic gene clusters (SMBGCs) have been proven to be crucial for pathogen virulence. A previous study showed that V. mali genome contains remarkably expanded SMBGCs and some of their genes were significantly upregulated during infection. In this study, we focus on LaeA, a known regulator of secondary metabol ...[more]

PMID: 33250871

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