Proteomics

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Bifidobacterium infantis metabolizes 2´fucosyllactose-derived and free fucose through a common catabolic pathway resulting in 1,2-propanediol secretion

ABSTRACT: Human milk oligosaccharides (HMOs) are highly diverse complex carbohydrates secreted in human milk. HMOs are indigestible by the infant and instead are metabolized by bifidobacteria in the infant gut microbiome to produce molecules that promote infant health and development. 2´fucosyllactose (2´FL) is an abundant HMO and is utilized by Bifidobacterium longum subsp. infantis, a predominant member of the infant gut microbiome. Currently, there is not a scientific consensus on how or if bifidobacteria metabolize the fucose portion of 2´FL or free fucose. This proteomic analysis was conducted in order to characterize the metabolic pathway by which B. infantis utilizes fucose.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bifidobacterium Longum Subsp. Infantis (strain Atcc 15697 / Dsm 20088 / Jcm 1222 / Nctc 11817 / S12)

TISSUE(S): Primary Cell Line Cell

SUBMITTER: Asha Rani  

LAB HEAD: David A. Sela

PROVIDER: PXD021868 | Pride | 2021-03-17

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
11929_14-F.mgf Mgf
11929_14-F.pep.xml Pepxml
11930_15-F.mgf Mgf
11930_15-F.pep.xml Pepxml
11931_16-F.mgf Mgf
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Publications

<i>Bifidobacterium infantis</i> Metabolizes 2'Fucosyllactose-Derived and Free Fucose Through a Common Catabolic Pathway Resulting in 1,2-Propanediol Secretion.

Dedon Liv R LR   Özcan Ezgi E   Rani Asha A   Sela David A DA  

Frontiers in nutrition 20201124

Human milk oligosaccharides (HMOs) enrich beneficial bifidobacteria in the infant gut microbiome which produce molecules that impact development and physiology. 2'fucosyllactose (2'FL) is a highly abundant fucosylated HMO which is utilized by <i>Bifidobacterium longum</i> subsp. <i>infantis</i>, despite limited scientific understanding of the underlying mechanism. Moreover, there is not a current consensus on whether free fucose could be metabolized when not incorporated in a larger oligosacchar  ...[more]

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