Dataset Information
Analysis of innate immune antagonism by SARS-CoV-2 reveals options for therapeutic immune modulation and differences to SARS-CoV
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MODEL1109130000MODEL1909260003MODEL1909260004MODEL1703310000MODEL1909260005MODEL1909260006MODEL1311110000MODEL1311110001
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human) Severe Acute Respiratory Syndrome Coronavirus 2
DISEASE(S): Severe Acute Respiratory Syndrome Coronavirus 2
SUBMITTER: 
Ignasi Forne
LAB HEAD: Prof. Dr. Axel Imhof
PROVIDER: PXD021899 | Pride | 2021-06-23
REPOSITORIES: Pride
Dataset's files
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Publications
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Cell reports 20210427 7
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate immune responses but may still be vulnerable to some. Here, we systematically analyze the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy. We show that SARS-CoV-2 proteins synergize to counteract anti-viral immune responses. For example, Nsp14 targets the type I IFN receptor for lysosomal degradation, ORF3a prevents fusion of autophagosomes and lysosomes, and ORF7a interferes with autophagos ...[more]
