Dataset Information

Human prostate cancer and Lysine succinylation

ABSTRACT: : Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Using quantitative global succinylome analysis, we characterized a significant increase of lysine 118 succinylation (K118su) of lactate dehydrogenase A (LDHA), which plays a role in increasing LDHA activity. As a substrate of SIRT5, LDHA-K118su significantly increased the migration and invasion of PCa cells and LDHA activity in PCa patients.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell Of Prostate, Cell Culture

DISEASE(S): Prostate Cancer

SUBMITTER: Oh Kwang Kwon

LAB HEAD: Sangkyu Lee

PROVIDER: PXD022005 | Pride | 2023-06-21

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20180318_PC3-PC3M_SILAC_AS_2hr_F0-1.raw	Raw
	20180318_PC3-PC3M_SILAC_AS_2hr_F0-2.raw	Raw
	201803_PC3-PC3M_SILAC_1st-batch_Ksucc_1st.raw	Raw
	201803_PC3-PC3M_SILAC_1st-batch_Ksucc_2nd.raw	Raw
	201803_PC3-PC3M_SILAC_1st-batch_Ksucc_3rd.raw	Raw

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Publications

LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.

Kwon Oh Kwang OK Bang In Hyuk IH Choi So Young SY Jeon Ju Mi JM Na Ann-Yae AY Gao Yan Y Cho Sam Seok SS Ki Sung Hwan SH Choe Youngshik Y Lee Jun Nyung JN Ha Yun-Sok YS Bae Eun Ju EJ Kwon Tae Gyun TG Park Byung-Hyun BH Lee Sangkyu S

Genomics, proteomics & bioinformatics 20220309 1

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Around 80% of the patients who developed advanced PCa suffered from bone metastasis, with a sharp drop in the survival rate. Despite great efforts, the detailed mechanisms underlying castration-resistant PCa (CRPC) remain unclear. Sirtuin 5 (SIRT5), an NAD<sup>+</sup>-dependent desuccinylase, is hypothesized to be a key regulator of various cancers. However, compared to other SIRTs, the role of SIRT5 in cancer ...[more]

PMID: 35278714

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