Dataset Information

Elucidation of BMI1, RYBP and H2AK119ub interactomes in Glioblastoma

ABSTRACT: Identification of BMI1, RYBP and H2AK119UB interactome in Glioblastoma (GBM) to elucidate BMI1 roles independent of the PRC1-complex in GBM.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Glioblastoma Cell Line

DISEASE(S): Glioblastoma

SUBMITTER: Vinothini Rajeeve

LAB HEAD: Pedro R Cutillas

PROVIDER: PXD022057 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.

Freire-Benéitez Verónica V Pomella Nicola N Millner Thomas O TO Dumas Anaëlle A AA Niklison-Chirou Maria Victoria MV Maniati Eleni E Wang Jun J Rajeeve Vinothini V Cutillas Pedro P Marino Silvia S

NAR cancer 20210322 1

Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Complex 1 (PRC1), which promotes the H2AK119ub catalytic activity of Ring1B, is upregulated in GBM and its tumorigenic role has been shown <i>in vitro</i> and <i>in vivo</i>. Here, we have used protein and chromatin immunoprecipitation followed by mass s ...[more]

PMID: 34316702

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