Dataset Information

Protein (elafin) cleavage by the main Lactobacillus spp encountered in the female gynecological tract

ABSTRACT: Mass spectrometry analyses for determining whether 13C615N2-labeled lysines contained in the elafin (innate peptide highly expressed in lower female genital tract and down-regulated in case of HPV infection) were found in the amino acid sequence of some proteins of Lactobacilli, supporting the fundamental role of innate secretion in the growth/survival of acid lactic bacteria (L. crispatus, L. jensenii and L. iners).

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Lactobacillus

SUBMITTER: Dominique Baiwir

LAB HEAD: Michael Herfs

PROVIDER: PXD022113 | Pride | 2022-04-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	200911-MClass-20-002124-11-AXM-3.msf	Msf
	200911-MClass-20-002124-11-AXM.raw	Raw
	200911-MClass-20-002230-09-AXM-2.msf	Msf
	200911-MClass-20-002230-09-AXM.raw	Raw
	200911-MClass-20-002232-09-AXM-2.msf	Msf

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Publications

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources.

Lebeau Alizee A Bruyere Diane D Roncarati Patrick P Peixoto Paul P Hervouet Eric E Cobraiville Gael G Taminiau Bernard B Masson Murielle M Gallego Carmen C Mazzucchelli Gabriel G Smargiasso Nicolas N Fleron Maximilien M Baiwir Dominique D Hendrick Elodie E Pilard Charlotte C Lerho Thomas T Reynders Celia C Ancion Marie M Greimers Roland R Twizere Jean-Claude JC Daube Georges G Schlecht-Louf Geraldine G Bachelerie Françoise F Combes Jean-Damien JD Melin Pierrette P Fillet Marianne M Delvenne Philippe P Hubert Pascale P Herfs Michael M

Nature communications 20220228 1

Despite the high prevalence of both cervico-vaginal human papillomavirus (HPV) infection and bacterial vaginosis (BV) worldwide, their causal relationship remains unclear. While BV has been presumed to be a risk factor for HPV acquisition and related carcinogenesis for a long time, here, supported by both a large retrospective follow-up study (n = 6,085) and extensive in vivo data using the K14-HPV16 transgenic mouse model, we report a novel blueprint in which the opposite association also exist ...[more]

PMID: 35228537

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