Proteomics

Dataset Information

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Plasma proteomics to discover diagnostic biomarker for Alzheimer's disease

ABSTRACT: The project aims to find diagnostic biomarkers for Alzheimer's disease in plasma. We applied discovery based proteomics was used to detect changes in proteins due to Alzheimer's disease using plasma samples collected from four study groups (African American Alzheimer's disease & cognitively normal, non-Hispanic-White Alzheimer's disease & cognitively normal). The data emphesizes the need for inclusion in Alzheimer's disease research.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Alzheimer's Disease

SUBMITTER: Mostafa Khan  

LAB HEAD: Rena AS Robinson

PROVIDER: PXD022265 | Pride | 2021-03-07

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Set2_Batch1_Frac01_01.msf Msf
Set2_Batch1_Frac01_01.raw Raw
Set2_Batch1_Frac01_02.msf Msf
Set2_Batch1_Frac01_02.raw Raw
Set2_Batch1_Frac02_01.msf Msf
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Publications

Why Inclusion Matters for Alzheimer's Disease Biomarker Discovery in Plasma.

Khan Mostafa J MJ   Desaire Heather H   Lopez Oscar L OL   Kamboh M Ilyas MI   Robinson Renã A S RAS  

Journal of Alzheimer's disease : JAD 20210101 3

<h4>Background</h4>African American/Black adults have a disproportionate incidence of Alzheimer's disease (AD) and are underrepresented in biomarker discovery efforts.<h4>Objective</h4>This study aimed to identify potential diagnostic biomarkers for AD using a combination of proteomics and machine learning approaches in a cohort that included African American/Black adults.<h4>Methods</h4>We conducted a discovery-based plasma proteomics study on plasma samples (N = 113) obtained from clinically d  ...[more]

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