Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480, Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: Mario Oroshi
LAB HEAD: Matthias Mann
PROVIDER: PXD022384 | Pride | 2022-06-13
REPOSITORIES: Pride
Stafford Che A CA Gassauer Alicia-Marie AM de Oliveira Mann Carina C CC Tanzer Maria C MC Fessler Evelyn E Wefers Benedikt B Nagl Dennis D Kuut Gunnar G Sulek Karolina K Vasilopoulou Catherine C Schwojer Sophia J SJ Wiest Andreas A Pfautsch Marie K MK Wurst Wolfgang W Yabal Monica M Fröhlich Thomas T Mann Matthias M Gisch Nicolas N Jae Lucas T LT Hornung Veit V
Nature 20220824 7927
Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell wall that consists of peptidoglycan (PGN), a polymeric structure comprising alternating amino sugars that form strands cross-linked by short peptides. Muramyl dipeptide (MDP) has been well documented as a minimal immunogenic component of peptidoglycan<sup>1-3</sup>. MDP is sensed by the cyt ...[more]