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Potential Functions of Histone H3.3K56 Acetylation in Mammals

ABSTRACT: To decipher the functions of histone H3.3 acetylation at lysine 56 in mammals using a cellular system.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Lei Fang

LAB HEAD: Lei Fang

PROVIDER: PXD022580 | Pride | 2022-06-09

REPOSITORIES: Pride

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			Action	DRS
	20161010-01.wiff	Wiff
	20161010-01.wiff.scan	Wiff
	20161010-02.wiff	Wiff
	20161010-02.wiff.scan	Wiff
	20161010-03.wiff	Wiff

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Publications

Potential functions of histone H3.3 lysine 56 acetylation in mammals.

Fang Lei L Chen Danqi D Zhang Jingzi J Li Hongjie H Bradford Beatrix B Jin Chunyuan C

Epigenetics 20210524 5

H3K56 acetylation (H3K56Ac) was first identified in yeast and has recently been reported to play important roles in maintaining genomic stability, chromatin assembly, DNA replication, cell cycle progression and DNA repair. Although H3.1K56Ac has been relatively well studied, the function of H3.3K56Ac remains mostly unknown in mammals. In this study, we used H3.3K56Q and H3.3K56R mutants to study the possible function of H3.3K56 acetylation. The K-to-Q substitution mimics a constitutively acetyla ...[more]

PMID: 33902396

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