Proteomics

Dataset Information

0

Diagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (4)

ABSTRACT: Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 cases, we selected 55 typical cases to build the first HCA proteomic database. Biopsies proteomic patterns allowed HCA classification, even for complex cases. In addition, these data gave access to a malignancy pattern identifying the HCA transformation. This pioneering work proposes a proteomic based machine learning tool, operational on fixed biopsies, to improve HCA diagnosis and therefore patient’s management.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

DISEASE(S): Hepatocellular Adenoma

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Raymond Anne-Aurelie

PROVIDER: PXD022844 | Pride | 2021-06-11

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
F008793.dat Other
F008794.dat Other
F008795.dat Other
F008803.dat Other
F008804.dat Other
Items per page:
1 - 5 of 192
altmetric image

Publications

<h4>Background and aims</h4>Through an exploratory proteomic approach based on typical hepatocellular adenomas (HCAs), we previously identified a diagnostic biomarker for a distinctive subtype of HCA with high risk of bleeding, already validated on a multicenter cohort. We hypothesized that the whole protein expression deregulation profile could deliver much more informative data for tumor characterization. Therefore, we pursued our analysis with the characterization of HCA proteomic profiles, e  ...[more]

Similar Datasets

Proteomics Diagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (3)
2021-06-11 | PXD022839 | Pride
Proteomics Diagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (1)
2021-06-11 | PXD022835 | Pride
Proteomics Diagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (2)
2021-06-11 | PXD022837 | Pride
Proteomics Diagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (5)
2021-06-11 | PXD023000 | Pride
Proteomics Identification of proteomic markers in head and neck cancer using MALDI-MS Imaging, LC-MS/MS and IHC
2018-11-14 | PXD009144 | Pride
Proteomics Proteomic analysis of Hepatocellular Adenoma
2018-03-14 | PXD005571 | Pride
Proteomics The non-apoptotic function of Caspase-8 in negatively regulating the CDK9 mediated Ser2 phosphorylation of RNA Polymerase II in cervical cancer
2023-03-11 | PXD038102 | Pride
Proteomics Proteomic analysis of primary human microvascular endothelial cells (HMVECs) stimulated for 24 h with either 50 ï�g/mL recombinant Fibrillin-1 C-terminal fragment or 25 ng/ml VEGF-A compared to unstimulated cells.
2023-05-31 | PXD029834 | Pride
Transcriptomics Integrated mRNA and miRNA expression profiling in blood reveals candidate biomarkers associated with endurance exercise in horse
2016-09-04 | E-GEOD-73104 | biostudies-arrayexpress
Proteomics BioID with P. falciparum protein PhiL1
2021-05-03 | PXD024237 | Pride