Dataset Information

Serum proteomics of sng- and pain-trend fibromyalgia patients

ABSTRACT: Fibromyalgia (FM) is a chronic pain condition and consists of widespread pain with similarities to neuropathic pain in clinical findings, pathophysiology, and neuropharmacology. Its mechanisms are poorly understood and a lack of effective biomarkers for diagnosis and onset prediction. This study aimed to identify the metabolites to characterize pain and sngception (Sng) in FM.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Fibromyalgia

SUBMITTER: Wei-Chi Ku

LAB HEAD: Wei-Chi Ku

PROVIDER: PXD022886 | Pride | 2022-08-12

REPOSITORIES: Pride

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Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia.

Hsu Wei-Hsiang WH Han Der-Sheng DS Ku Wei-Chi WC Chao Yen-Ming YM Chen Chih-Cheng CC Lin Yun-Lian YL

European journal of pain (London, England) 20211026 2

<h4>Background</h4>Fibromyalgia (FM) is characterized by chronic widespread pain. Its pathophysiological mechanisms remain poorly understood, and effective diagnosis and treatments are lacking. This study aimed to identify significantly changed biosignatures in FM and propose a novel classification for FM based on pain and soreness (sng) symptoms.<h4>Methods</h4>Urine and serum samples from 30 FM patients and 25 controls underwent metabolomic and proteomic profiling.<h4>Results</h4>Compared with ...[more]

PMID: 34608709

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