Proteomics

Dataset Information

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The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted host antiviral signaling and translation


ABSTRACT: To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Yen-Yu Yang  

LAB HEAD: Yinsheng Wang

PROVIDER: PXD023239 | Pride | 2022-02-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
SARS_Weili_1.raw Raw
SARS_Weili_10.raw Raw
SARS_Weili_11.raw Raw
SARS_Weili_12.raw Raw
SARS_Weili_13.raw Raw
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Publications


Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics. This identified viral proteins at specific intracellular locations, such as association of accessary proteins with intracellular membranes, and projected SARS-CoV-2 impacts on innate immune signaling, ER-Golgi transport, and protein translation. It i  ...[more]

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