Dataset Information

Quantitative Analysis of Lysine Acetylation in A549 Cell Line

ABSTRACT: C-C Motif Chemokine 18 (CCL18) belongs to the chemokine CC family and is predominantly secreted by M2-tumor associated macrophage (TAMs). It has been reported to be associated with various diseases and malignancies. Previous study showed that CCL18 promotes metastasis by activating downstream kinases. However, it remains unknown whether CCL18 regulates post-translational modifications, other than phosphorylation, during tumorigenesis. Here, we demonstrate that CCL18 is up-regulated in non-small cell lung cancer (NSCLC) and is involved in regulating the lysine acetylome in A549 cells. Using the combination of SILAC labeling and high-efficiency acetylation enrichment methods

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: kong shuai

LAB HEAD: Fengsong wang

PROVIDER: PXD023468 | Pride | 2021-02-16

REPOSITORIES: Pride

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Global analysis of lysine acetylome reveals the potential role of CCL18 in non-small cell lung cancer.

Kong Shuai S Ding Lu L Fan Chenkun C Li Yun Y Wang Chi C Wang Ke K Xu Weilong W Shi Xuanming X Wu Quan Q Wang Fengsong F

Proteomics 20210308 7-8

C-C motif chemokine 18 (CCL18) belongs to the chemokine CC family and is predominantly secreted by M2-tumor-associated macrophages. It has been reported to be associated with various diseases and malignancies. Previous studies showed that CCL18 promotes metastasis by activating downstream kinases. However, it remains unknown whether CCL18 regulates post-translational modifications, other than phosphorylation, during tumorigenesis. Here, we demonstrate that CCL18 is up-regulated in non-small cell ...[more]

PMID: 33570763

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			Action	DRS
	6362SP_Kac_rep1_search.zip	Other
	6362SP_Kac_rep2_search.zip	Other
	6362SP_Kac_rep3_search.zip	Other
	6362SP_rep1_1.raw	Raw
	6362SP_rep1_2.raw	Raw