Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Yu Lu
LAB HEAD: Yu Lu
PROVIDER: PXD023523 | Pride | 2022-02-16
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
RAP-SY5Y-GAPDH-1.msf | Msf | |||
RAP-SY5Y-GAPDH-1.raw | Raw | |||
RAP-SY5Y-GAPDH-2.msf | Msf | |||
RAP-SY5Y-GAPDH-2.raw | Raw | |||
RAP-SY5Y-TAU-1.msf | Msf |
Items per page: 5 1 - 5 of 8 |
Xing Sansi S Wang Jane J Wu Ruilin R Hefti Marco M MM Crary John F JF Lu Yu Y
RNA biology 20211231 1
Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which have equal abundance in healthy adult human brain. Aberrant alternative splicing in Tau exon 10 leads to distortion of the balanced 3 R- and 4 R-Tau expression levels, which is a causal factor to trigger toxic Tau aggregation, neuron dysfunction and patient death in a group of neurodegenerative diseases known as tauopathies. Hence, identification of regulators upstream of the Tau exon 10 splicing events are crucial ...[more]