Dataset Information

Rifampicin-mouse liver proteomics

ABSTRACT: Tuberculosis is one of top causes of death among curable infectious diseases; it is an airborne infectious disease that kills 2 million people worldwide. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI). Rifampicin is one of the most common anti-tuberculosis therapies and has well-known hepatotoxicity. To understand the mechanism of rifampicin-induced liver injury, we performed a global proteomic analysis of liver proteins by LC-MS/MS in a mouse model after the oral administration of 177 and 442.5 mg/kg rifampicin (LD10 and LD25) for 14 days. Based on the biochemical parameters in the plasma after rifampicin treatment, the hepatotoxic effect of rifampicin in the mouse liver was defined as a mixed liver injury. In the present study, we identified 1,101 proteins and quantified 1,038 proteins. A total of 29 and 40 proteins were up-regulated and 27 and 118 proteins were down-regulated in response to 177 and 442.5 mg/kg rifampicin, respectively.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Oh Kwang Kwon

LAB HEAD: Sangkyu Lee

PROVIDER: PXD006313 | Pride | 2017-07-10

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20160901_Mouseliver_rifam_TMT_frac01.raw	Raw
	20160901_Mouseliver_rifam_TMT_frac02.raw	Raw
	20160901_Mouseliver_rifam_TMT_frac03.raw	Raw
	20160901_Mouseliver_rifam_TMT_frac04.raw	Raw
	20160901_Mouseliver_rifam_TMT_frac05.raw	Raw

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Publications

Mechanism Investigation of Rifampicin-Induced Liver Injury Using Comparative Toxicoproteomics in Mice.

Kim Ju-Hyun JH Nam Woong Shik WS Kim Sun Joo SJ Kwon Oh Kwang OK Seung Eun Ji EJ Jo Jung Jae JJ Shresha Riya R Lee Tae Hee TH Jeon Tae Won TW Ki Sung Hwan SH Lee Hye Suk HS Lee Sangkyu S

International journal of molecular sciences 20170702 7

Tuberculosis is one of the top causes of death among curable infectious diseases; it is an airborne infectious disease that killed 1.1 million people worldwide in 2010. Anti-tuberculosis drug-induced liver injury is the primary cause of drug-induced liver injury (DILI). Rifampicin is one of the most common anti-tuberculosis therapies and has well-known hepatotoxicity. To understand the mechanism of rifampicin-induced liver injury, we performed a global proteomic analysis of liver proteins by LC- ...[more]

PMID: 28671602

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