Dataset Information

The production of Excretory-Secretory molecules from Heligmosomoides polygyrus bakeri fourth stage larvae varies between mixed and single sex cultures.

ABSTRACT: In this study, the composition of ES of male and female L4 stage Heligmosomoides polygyrus bakeri in the presence (cultured together) or absence (cultured alone) of the opposite sex was examined using mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Heligmosomoides Polygyrus Bakeri

SUBMITTER: Ludmiła Szewczak

LAB HEAD: Katarzyna Donskow-Łysoniewska

PROVIDER: PXD023759 | Pride | 2021-09-10

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	90415570maru_ESHP_MIX.mzid.gz	Mzid
	90415570maru_ESHP_MIX.raw	Raw
	90415571maru_ESHP_MALE.mzid.gz	Mzid
	90415571maru_ESHP_MALE.raw	Raw
	90415572maru_ESHP_FEMALE.mzid.gz	Mzid

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The production of excretory-secretory molecules from Heligmosomoides polygyrus bakeri fourth stage larvae varies between mixed and single sex cultures.

Maruszewska-Cheruiyot Marta M Szewczak Ludmiła L Krawczak-Wójcik Katarzyna K Głaczyńska Magdalena M Donskow-Łysoniewska Katarzyna K

Parasites & vectors 20210208 1

<h4>Background</h4>Excretory-secretory (ES) products are crucial in maintaining helminths in the host. Consequently, the proteins of ES are potential vaccine molecules and potential therapeutic agents for autoimmune diseases. Heligmosomoides polygyrus bakeri, a gastrointestinal parasite of mice, is a model of hookworm infection in humans. ES produced by both sexes of H. polygyrus bakeri L4 stage cultured separately shows different immunomodulatory properties than ES obtained when both sexes are ...[more]

PMID: 33557937

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