Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Blood
DISEASE(S): Acute Leukemia
SUBMITTER: Rozbeh Jafari
LAB HEAD: Rozbeh Jafari
PROVIDER: PXD024040 | Pride | 2021-08-23
REPOSITORIES: Pride
Items per page: 1 - 5 of 46 |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20210701 7
Polo-like kinase 1 (PLK1) is an important cell cycle kinase and an attractive target for anticancer treatments. An ATP-competitive small molecular PLK1 inhibitor, volasertib, has reached phase III in clinical trials in patients with refractory acute myeloid leukemia as a combination treatment with cytarabine. However, severe side effects limited its use. The origin of the side effects is unclear and might be due to insufficient specificity of the drug. Thus, identifying potential off-targets to ...[more]