Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hek-293t Cell, Kidney Epithelial Cell
SUBMITTER: Ruth Huttenhain
LAB HEAD: Nevan Krogan
PROVIDER: PXD024127 | Pride | 2022-10-14
REPOSITORIES: Pride
Action | DRS | |||
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Experimental_design_SET3_mutants_Flag.txt | Txt | |||
Experimental_design_SETD3_2A_purification.txt | Txt | |||
Experimental_design_SETD3_flag.txt | Txt | |||
SETD3_IP_evidence.txt | Txt | |||
SETD3_IP_peptides.txt | Txt |
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Nature communications 20220908 1
Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed therapies present an enticing option for this diverse genus of viruses. We have previously identified the actin histidine methyltransferase SETD3 as a critical host factor physically interacting with the viral protease 2A. Here, we report the 3.5 Å cryo-EM structure of SETD3 interacting with coxsackievirus B3 2A at two distinct interfaces, inclu ...[more]