Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Nathaniel Robinson
LAB HEAD: William Schiemann
PROVIDER: PXD024141 | Pride | 2022-02-16
REPOSITORIES: Pride
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Robinson Nathaniel J NJ Miyagi Masaru M Scarborough Jessica A JA Scott Jacob G JG Taylor Derek J DJ Schiemann William P WP
Science signaling 20210629 689
The maintenance of telomere length supports repetitive cell division and therefore plays a central role in cancer development and progression. Telomeres are extended by either the enzyme telomerase or the alternative lengthening of telomeres (ALT) pathway. Here, we found that the telomere-associated protein SLX4IP dictates telomere proteome composition by recruiting and activating the E3 SUMO ligase PIAS1 to the SLX4 complex. PIAS1 SUMOylated the telomere-binding protein RAP1, which disrupted it ...[more]