Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Frank Stein
LAB HEAD: Andrea Cerase
PROVIDER: PXD024155 | Pride | 2021-09-10
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 14 |
Cerase Andrea A Young Alexander N AN Ruiz Nerea Blanes NB Buness Andreas A Sant Gabrielle M GM Arnold Mirjam M Di Giacomo Monica M Ascolani Michela M Kumar Manish M Hierholzer Andreas A Trigiante Giuseppe G Marzi Sarah J SJ Avner Philip P
Communications biology 20210415 1
Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-regulated and spreads along the future inactive X chromosome. Contextually, it recruits repressive histone and DNA modifiers that transcriptionally silence the X chromosome. Xist regulation is tightly coupled to differentiation and its expression is ...[more]