Proteomics

Dataset Information

0

Pre and post ATRA/VP treatment proteomic and phophoproteomic profiling of AML responders and non-responders


ABSTRACT: Proteome and phosphoproteome raw files from AML patient samples obtained before and after 3 and 8 days of ATRA/valproic acid treatment

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Maria Hernandez-Valladares  

LAB HEAD: Maria Hernandez Valladares

PROVIDER: PXD024197 | Pride | 2021-09-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
AT1-T1_x1.raw Raw
AT1-T1_x2.raw Raw
AT1-T1_x3.raw Raw
AT1-T2_x1.raw Raw
AT1-T2_x2.raw Raw
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Publications

Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid.

Hernandez-Valladares Maria M   Wangen Rebecca R   Aasebø Elise E   Reikvam Håkon H   Berven Frode S FS   Selheim Frode F   Bruserud Øystein Ø  

Cancers 20210429 9


All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and improve normal peripheral blood cell counts. In this context, we used a proteomic/phosphoproteomic strategy to investigate the in vivo effects of ATRA/VP on human AML cells. Before starting the combined treatment, AML responders showed increased levels of several proteins, espe  ...[more]

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