Proteomics

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Proteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment

ABSTRACT: Searching for new strategies of acute myeloid leukemia (AML) treatment is of particular interest. Cell lines, e. g. HL-60 and NB4, represent model systems to study molecular features of leukemic cells. The all-trans-retinoic acid (ATRA) has proven itself to be an effective treatment for one of AML subtypes, i.e., acute promyelocytic leukemia (APL). At the same time, ATRA causes granulocytic differentiation of non-APL leukemic cells in vitro. Combination of new therapeutics with ATRA could improve efficiency of treatment. Studying the proteome perturbation in leukemic cells under the ATRA treatment allows to determine potential regulatory molecules that could be affected pharmacologically. Thus, the TMT-based proteomic profiles of HL-60, NB4, and K562 cell lines under the ATRA treatment were obtained at 0, 3, 12, 24, and 72 h after the ATRA treatment.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Svetlana Novikova  

LAB HEAD: Victor Zgoda

PROVIDER: PXD050317 | Pride | 2024-06-23

REPOSITORIES: Pride

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270122RNF_NSE_TMT01.raw Raw
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Publications

Systems Biology for Drug Target Discovery in Acute Myeloid Leukemia.

Novikova Svetlana S   Tolstova Tatiana T   Kurbatov Leonid L   Farafonova Tatiana T   Tikhonova Olga O   Soloveva Natalia N   Rusanov Alexander A   Zgoda Victor V  

International journal of molecular sciences 20240423 9

Combining new therapeutics with all-<i>trans</i>-retinoic acid (ATRA) could improve the efficiency of acute myeloid leukemia (AML) treatment. Modeling the process of ATRA-induced differentiation based on the transcriptomic profile of leukemic cells resulted in the identification of key targets that can be used to increase the therapeutic effect of ATRA. The genome-scale transcriptome analysis revealed the early molecular response to the ATRA treatment of HL-60 cells. In this study, we performed  ...[more]

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