Proteomics

Dataset Information

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Alterations in the HLA-B*57:01 immunopeptidome by flucloxacillin and immunogenicity of drug-haptenated peptides


ABSTRACT: Flucloxacillin (FLX), a -lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, B-lymphoblast Cell Line

SUBMITTER: Swamy Kumar Polumuri  

LAB HEAD: Michael A. Norcross, MD Montserrat Puig, PhD

PROVIDER: PXD024212 | Pride | 2021-02-17

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
B721.5701_FLX1a.raw Raw
B721.5701_FLX_1b.raw Raw
B721.5701_FLX_2a.raw Raw
B721.5701_FLX_2b.raw Raw
B721.5701_Medium1a.raw Raw
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