Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human) Hiv-1 M:b_hxb2r
TISSUE(S): B Cell, Cell Suspension Culture
SUBMITTER: Sri Ramarathinam
LAB HEAD: Anthony Purcell
PROVIDER: PXD004471 | Pride | 2018-02-19
REPOSITORIES: Pride
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Proteomics 20180410 12
The recognition of pathogen-derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antigens are degraded in the cytosol and short peptides assemble with class I human leukocyte antigen (HLA) molecules in the ER. These peptide-HLA complexes egress to the cell surface and are scrutinized by cytotoxic CD8+ T-cells leading to the eradication of the infected cell. Here, naturally presented HLA-B*57:01 bound peptides derived from the envelope protein of the hu ...[more]