Characterization of circulating extracellular vesides of steroid sensitive nephrotic syndrome patients
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma, Extracellular Vesicle
DISEASE(S): Nephrotic Syndrome
SUBMITTER: 
ulku guler
LAB HEAD: Bekir Salih
PROVIDER: PXD024217 | Pride | 2022-02-16
REPOSITORIES: Pride
Publications
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes.
Eroglu Fehime K FK Yazar Volkan V Guler Ulku U Yıldırım Muzaffer M Yildirim Tugce T Gungor Tulin T Celikkaya Evra E Karakaya Deniz D Turay Nilsu N Ciftci Dede Eda E Korkusuz Petek P Salih Bekir B Bulbul Mehmet M Gursel Ihsan I
American journal of physiology. Renal physiology 20210927 5
Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (NS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source of such a soluble mediator. Here, we aimed to characterize and try to delineate the effects of these EVs in vitro. Plasma EVs from 20 children with steroid-sensitive NS in relapse and remission, 10 healthy controls, and 6 disease controls were obtained by serial ultracentrifugati ...[more]
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