Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Olga Shevchuk
LAB HEAD: Prof. Dr. Albert Sickmann
PROVIDER: PXD024480 | Pride | 2022-05-10
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
BioID_Nsp2.msf | Msf | |||
Lumos09463.msf | Msf | |||
Lumos09463.raw | Raw | |||
Lumos09464.raw | Raw | |||
Lumos09465.raw | Raw |
Items per page: 5 1 - 5 of 68 |
Bujanic Lucija L Shevchuk Olga O von Kügelgen Nicolai N Kalinina Anna A Ludwik Katarzyna K Koppstein David D Zerna Nadja N Sickmann Albert A Chekulaeva Marina M
RNA (New York, N.Y.) 20220301 5
SARS-CoV-2, responsible for the ongoing global pandemic, must overcome a conundrum faced by all viruses. To achieve its own replication and spread, it simultaneously depends on and subverts cellular mechanisms. At the early stage of infection, SARS-CoV-2 expresses the viral nonstructural protein 1 (NSP1), which inhibits host translation by blocking the mRNA entry tunnel on the ribosome; this interferes with the binding of cellular mRNAs to the ribosome. Viral mRNAs, on the other hand, overcome t ...[more]