Proteomics

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Comparative proteomic profiling: cellular metabolisms are mainly affected in Senecavirus A-inoculated cells at an early stage of infection

ABSTRACT: Senecavirus A (SVA) belongs to the genus Senecavirus in the family Picornaviridae. It is increasingly used for proteomic research that tandem mass tag-labeled liquid chromatography-tandem mass spectrometry is combined with the parallel reaction monitoring technique. In this study, this combined method was used to uncover separately proteomic profiles of SVA- and non-infected BSR-T7/5 cells. Further, both proteomic profiles were compared with each other. The proteomic profiling showed that a total of 361 differentially expressed proteins were identified, out of which, 305 and 56 were upregulated and downregulated in SVA-infected cells at 12 h post-inoculation, respectively. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analyses showed that cellular metabolisms were mainly affected in SVA-inoculated cells at an early stage of infection.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)

TISSUE(S): Cell Culture

SUBMITTER: Guolin Li  

LAB HEAD: Fuxiao Liu

PROVIDER: PXD024947 | Pride | 2021-09-10

REPOSITORIES: Pride

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Comparative Proteomic Profiling: Cellular Metabolisms Are Mainly Affected in <i>Senecavirus</i> A-Inoculated Cells at an Early Stage of Infection.

Liu Fuxiao F   Ni Bo B   Wei Rong R  

Viruses 20210531 6

<i>Senecavirus</i> A (SVA), also known as Seneca Valley virus, belongs to the genus <i>Senecavirus</i> in the family <i>Picornaviridae</i>. SVA can cause vesicular disease and epidemic transient neonatal losses in pigs. This virus efficiently propagates in some non-pig-derived cells, like the baby hamster kidney (BHK) cell line and its derivate (BSR-T7/5). Conventionally, a few proteins or only one protein is selected for exploiting a given mechanism concerning cellular regulation after SVA infe  ...[more]

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