Proteomics

Dataset Information

0

ITRAQ analysis of Metformin treated AGS cells


ABSTRACT: AGS cells were treated with metformin then performed iTRAQ proteomics techniques.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stomach, Epithelium Of Stomach

DISEASE(S): Stomach Cancer

SUBMITTER: Wang Weihsuan  

LAB HEAD: Hsueh-Fen Juan

PROVIDER: PXD024996 | Pride | 2021-09-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Data_analysis.rar Other
Metformin_1.raw.rar Raw
Metformin_2.raw.rar Raw
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Publications

Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration.

Wang Wei-Hsuan WH   Chen Szu-Kai SK   Huang Hsuan-Cheng HC   Juan Hsueh-Fen HF  

ACS omega 20210526 22


Metformin is one of the most widely used anti-diabetic drugs in type-II diabetes treatment. The mechanism of decreasing blood glucose is believed to suppress hepatic gluconeogenesis by increasing muscular glucose uptake and insulin sensitivity. Recent studies suggest that metformin may reduce cancer risk; however, its anticancer mechanism in gastric cancers remains unclear. Here, we aim to evaluate the anticancer effects of metformin on human gastric adenocarcinoma (AGS) cells. Our results showe  ...[more]

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