Proteomics

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Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

ABSTRACT: Using omics tools with the SARS-CoV-2 infected Syrian hamster as model for COVID-19, along with published datasets from COVID-19 patients, Nouailles et al. present a detailed longitudinal analysis of systemic and pulmonary quantitative and qualitative immune responses in a moderate disease setting. Targeted analysis of the alveolar and microvascular niche revealed a dominant role for monocyte-derived macrophages and endothelial cells regarding early anti-viral genes as well as pro-inflammatory and T cell recruiting chemokine expression. Recruitment of cytotoxic effector T cells coincided with viral clearance. This combined response was favorable for a moderate and self-limited disease course.

INSTRUMENT(S): TripleTOF 6600, Q Exactive Plus

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Lung, Blood Serum

DISEASE(S): Covid-19

SUBMITTER: Michael Mülleder  

LAB HEAD: Michael Muelleder

PROVIDER: PXD025164 | Pride | 2021-06-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
200925_KTT_QEP_001_50-0024_trimpertGold_dia_GPF1.raw Raw
200925_KTT_QEP_001_50-0024_trimpertGold_dia_GPF1_201001151347.raw Raw
200925_KTT_QEP_002_50-0024_trimpertGold_dia_GPF2.raw Raw
200925_KTT_QEP_002_50-0024_trimpertGold_dia_GPF2_201001174049.raw Raw
200925_KTT_QEP_003_50-0024_trimpertGold_dia_GPF3.raw Raw
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Publications

In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly involving endothelial cells, remain ill-defined. Using Syrian hamsters as a model for moderate COVID-19, we conduct a detailed longitudinal analysis of systemic and pulmonary cellular responses, and corroborate it with datasets from COVID-19 patients. Monocyte-derived macrophages in lungs exert the earliest and stronges  ...[more]

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