Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Sus Scrofa Domesticus (domestic Pig) Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Sung-Hyun Jo
LAB HEAD: Seung-Woo Cho
PROVIDER: PXD025397 | Pride | 2021-06-02
REPOSITORIES: Pride
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Nature communications 20210805 1
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organoids. Here, we demonstrate two engineering elements to improve human brain organoid culture, (1) a human brain extracellular matrix to provide brain-specific cues and (2) a microfluidic device with per ...[more]