Proteomics

Dataset Information

0

Pulldown CG42797 vs S2 cell lysate


ABSTRACT: Pulldown of CG42797 protein vs S2 cell lysate. Stage diging protocol trypsin digestion.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: vittoria matafora  

LAB HEAD: Angela Bachi

PROVIDER: PXD025809 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
EM_SP_GST_01.mzid.gz Mzid
EM_SP_GST_01.mzid_EM_SP_GST_01.MGF Mzid
EM_SP_GST_01.raw Raw
EM_SP_GST_02.mzid.gz Mzid
EM_SP_GST_02.mzid_EM_SP_GST_02.MGF Mzid
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Publications

Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.

Fajner Valentina V   Giavazzi Fabio F   Sala Simona S   Oldani Amanda A   Martini Emanuele E   Napoletano Francesco F   Parazzoli Dario D   Cesare Giuliana G   Cerbino Roberto R   Maspero Elena E   Vaccari Thomas T   Polo Simona S  

Nature communications 20210916 1


Specialised ribonucleoprotein (RNP) granules are a hallmark of polarized cells, like neurons and germ cells. Among their main functions is the spatial and temporal modulation of the activity of specific mRNA transcripts that allow specification of primary embryonic axes. While RNPs composition and role are well established, their regulation is poorly defined. Here, we demonstrate that Hecw, a newly identified Drosophila ubiquitin ligase, is a key modulator of RNPs in oogenesis and neurons. Hecw  ...[more]

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