Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell
SUBMITTER: Jennifer Bethard
LAB HEAD: Wenjian Gan, Ph.D.
PROVIDER: PXD026071 | Pride | 2022-02-17
REPOSITORIES: Pride
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110819_WenjianGan_AKT1.msf | Msf | |||
110819_WenjianGan_AKT1.raw | Raw | |||
AKT1.fasta | Fasta | |||
Methyl__R_Sites.txt | Txt | |||
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Nature communications 20210608 1
AKT is involved in a number of key cellular processes including cell proliferation, apoptosis and metabolism. Hyperactivation of AKT is associated with many pathological conditions, particularly cancers. Emerging evidence indicates that arginine methylation is involved in modulating AKT signaling pathway. However, whether and how arginine methylation directly regulates AKT kinase activity remain unknown. Here we report that protein arginine methyltransferase 5 (PRMT5), but not other PRMTs, promo ...[more]