Proteomics

Dataset Information

0

Effect of HPV8-E7 expression on the phospho-proteome in keratinocytes


ABSTRACT: Human papillomavirus type 8 (HPV8) is associated with the development of non-melanoma skin cancer. In the past we already delved into the mechanisms involved in keratinocyte invasion, showing that the viral E7 oncoprotein is a key player that drives invasion of basal keratinocytes controlled by the extracellular protein fibronectin. To unravel further downstream effects in E7 expressing keratinocytes we now characterized alterations of the phospho-proteome in E7 expressing N/TERT keratinocytes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Keratinocyte, Skin

DISEASE(S): Skin Cancer

SUBMITTER: Prerana Wagle  

LAB HEAD: Baki Akgül

PROVIDER: PXD026099 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
1268_pp_msms.txt Txt
1268_pp_proteinGroups.txt Txt
1268_wp_msms.txt Txt
1268_wp_proteinGroups.txt Txt
1675_phos_msms.txt Txt
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Publications

Novel Insights Into Cellular Changes in HPV8-E7 Positive Keratinocytes: A Transcriptomic and Proteomic Analysis.

Kirschberg Matthias M   Syed Adnan Shahzad AS   Dönmez Hanife Güler HG   Heuser Sandra S   Wilbrand-Hennes Astrid A   Alonso Angel A   Hufbauer Martin M   Akgül Baki B  

Frontiers in microbiology 20210906


Human papillomavirus type 8 (HPV8) is associated with the development of non-melanoma skin cancer. In the past we already delved into the mechanisms involved in keratinocyte invasion, showing that the viral E7 oncoprotein is a key player that drives invasion of basal keratinocytes controlled by the extracellular protein fibronectin. To unravel further downstream effects in E7 expressing keratinocytes we now aimed at characterizing gene and protein/phosphoprotein alterations to narrow down on key  ...[more]

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