Dataset Information
Proteome profiling of brain tissue from multiple system atrophy patients and from controls
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Multiple System Atrophy
SUBMITTER: 
Ole Østergaard
LAB HEAD: Jesper Velgaard Olsen
PROVIDER: PXD026370 | Pride | 2022-08-12
REPOSITORIES: Pride
Dataset's files
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Publications
Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology.
Cellular and molecular life sciences : CMLS 20220603 6
<h4>Background</h4>Multiple system atrophy (MSA) is a rare, progressive, neurodegenerative disorder presenting glia pathology. Still, disease etiology and pathophysiology are unknown, but neuro-inflammation and vascular disruption may be contributing factors to the disease progression. Here, we performed an ex vivo deep proteome profiling of the prefrontal cortex of MSA patients to reveal disease-relevant molecular neuropathological processes. Observations were validated in plasma and cerebrospi ...[more]
