Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Caenorhabditis Elegans
SUBMITTER: Shinyeong Ju
LAB HEAD: Cheolju Lee
PROVIDER: PXD026411 | Pride | 2022-02-17
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 60 |
Jung Yoonji Y Artan Murat M Kim Nari N Yeom Jeonghun J Hwang Ara B AB Jeong Dae-Eun DE Altintas Özlem Ö Seo Keunhee K Seo Mihwa M Lee Dongyeop D Hwang Wooseon W Lee Yujin Y Sohn Jooyeon J Kim Eun Ji E EJE Ju Sungeun S Han Seong Kyu SK Nam Hyun-Jun HJ Adams Linnea L Ryu Youngjae Y Moon Dong Jin DJ Kang Chanhee C Yoo Joo-Yeon JY Park Sang Ki SK Ha Chang Man CM Hansen Malene M Kim Sanguk S Lee Cheolju C Park Seung-Yeol SY Lee Seung-Jae V SV
Science advances 20211203 49
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids. Defects in the Golgi apparatus lead to various diseases, but its role in organismal longevity is largely unknown. Using a quantitative proteomic approach, we found that a Golgi protein, MON-2, was up-regulated in long-lived <i>Caenorhabditis elegans</i> mutants with mitochondrial respiration defects and was required for their longevity. Similarly, we showed that DOP1/PAD-1, which acts with MON-2 to traff ...[more]