Proteomics

Dataset Information

0

BioID samples ARS2/ARS2c1/ARS2c2


ABSTRACT: BioID data. LC-MS/MS. Hek293T cell line. Biotinylation

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: monica mesa  

LAB HEAD: Perry Howard

PROVIDER: PXD026453 | Pride | 2022-04-04

REPOSITORIES: Pride

Dataset's files

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Publications

Cytoplasmic switch of ARS2 isoforms promotes nonsense-mediated mRNA decay and arsenic sensitivity.

Mesa-Perez Monica M   Hamilton Phineas T PT   Miranda Alex A   Brodie Nicholas N   O'Sullivan Connor C   Christie Jennifer J   Ryan Bridget C BC   Chow Robert L RL   Goodlett David D   Nelson Christopher J CJ   Howard Perry L PL  

Nucleic acids research 20220201 3


The life of RNA polymerase II (RNAPII) transcripts is shaped by the dynamic formation of mutually exclusive ribonucleoprotein complexes (RNPs) that direct transcript biogenesis and turnover. A key regulator of RNA metabolism in the nucleus is the scaffold protein ARS2 (arsenic resistance protein 2), bound to the cap binding complex (CBC). We report here that alternative splicing of ARS2's intron 5, generates cytoplasmic isoforms that lack 270 amino acids from the N-terminal of the protein and ar  ...[more]

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