Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hesc Cell, Embryonic Stem Cell
SUBMITTER: Xin Huang
LAB HEAD: Jianlong Wang
PROVIDER: PXD026556 | Pride | 2021-09-12
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 146 |
Huang Xin X Park Kyoung-Mi KM Gontarz Paul P Zhang Bo B Pan Joshua J McKenzie Zachary Z Fischer Laura A LA Dong Chen C Dietmann Sabine S Xing Xiaoyun X Shliaha Pavel V PV Yang Jihong J Li Dan D Ding Junjun J Lungjangwa Tenzin T Mitalipova Maya M Khan Shafqat A SA Imsoonthornruksa Sumeth S Jensen Nick N Wang Ting T Kadoch Cigall C Jaenisch Rudolf R Wang Jianlong J Theunissen Thorold W TW
Nature communications 20210826 1
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not to date been explored. Here we mapped the OCT4 interactomes in naïve and primed hESCs, revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 ...[more]