Proteomics

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OCT4 IP-MS in Naive and Primed Human ESCs

ABSTRACT: Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not to date been explored. Here we mapped the OCT4 interactomes in naïve and primed hESCs, revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hesc Cell, Embryonic Stem Cell

SUBMITTER: Xin Huang  

LAB HEAD: Jianlong Wang

PROVIDER: PXD026556 | Pride | 2021-09-12

REPOSITORIES: Pride

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Naive-BirA-FLAG-IP-MS150298-L3-1.raw Raw
Naive-BirA-FLAG-IP-MS150298-L3-2.raw Raw
Naive-BirA-FLAG-IP-MS150298-L3-3.raw Raw
Naive-BirA-FLAG-IP-MS150298-L3-4.raw Raw
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Publications

Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not to date been explored. Here we mapped the OCT4 interactomes in naïve and primed hESCs, revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4  ...[more]

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