Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Embryonic Stem Cell
SUBMITTER: Xin Huang
LAB HEAD: Jianlong Wang
PROVIDER: PXD033587 | Pride | 2022-06-10
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 14 |
Huang Xin X Bashkenova Nazym N Hong Yantao Y Lyu Cong C Guallar Diana D Hu Zhe Z Malik Vikas V Li Dan D Wang Hailin H Shen Xiaohua X Zhou Hongwei H Wang Jianlong J
Cell reports 20220601 10
TET1 maintains hypomethylation at bivalent promoters through its catalytic activity in embryonic stem cells (ESCs). However, TET1 catalytic activity-independent function in regulating bivalent genes is not well understood. Using a proteomics approach, we map the TET1 interactome in ESCs and identify PSPC1 as a TET1 partner. Genome-wide location analysis reveals that PSPC1 functionally associates with TET1 and Polycomb repressive complex-2 (PRC2). We establish that PSPC1 and TET1 repress, and the ...[more]