Dataset Information
Analysis of SARS-CoV-2 S protein by LC-MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2
SUBMITTER: 
Peng Zhao
LAB HEAD: Lance Wells
PROVIDER: PXD026560 | Pride | 2021-06-08
REPOSITORIES: Pride
Dataset's files
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Publications
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
Cell host & microbe 20200824 4
The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of human ACE2. We combined this information with bioinformatics analyses of natural variants and with existi ...[more]
