Proteomics

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Comparative Proteomic Analysis of retro-oil fluid and vitreous fluid from patients

ABSTRACT: There have been reports of unexplained visual loss following intra-ocular silicone oil (SiO) tamponade in retinal detachment patients, yet the underlying mechanism is unknown. In the present study, we identified differentially expressed proteins in the vitreous humor of four groups (each group, n=3): pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RD group), SiO removal after successful retinal reattachment (SO group), cataract surgery after successful retinal reattachment with sterilized air tamponade (FA group), and PPV for epiretinal membrane (ERM group). DIA was combined with two-dimensional liquid chromatography-tandem mass spectrometry (LC-MS/MS) to find expression changes in the proteome of vitreous.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vitreous Humor

SUBMITTER: Yiyang Shu  

LAB HEAD: Haiyun Liu

PROVIDER: PXD026816 | Pride | 2022-02-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
P190001-DIA_DIRECT_Peptides_Report.xls Xls
P190001-DIA_DIRECT_Protein_Report.xls Xls
P190001-ERM1.raw Raw
P190001-ERM2.raw Raw
P190001-ERM3.raw Raw
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Publications

DIA Comparative Proteomic Analysis of Retro-oil Fluid and Vitreous Fluid From Retinal Detachment Patients.

Shu Yiyang Y   Gao Min M   Zhou Yifan Y   Liu Haiyun H   Sun Xiaodong X  

Frontiers in molecular biosciences 20211203

<b>Objectives:</b> There have been reports of unexplained visual loss following intra-ocular silicone oil (SiO) tamponade in retinal detachment patients, yet the underlying mechanism is unknown. The aim of this study was to investigate the mechanisms behind retinal toxicity following intra-ocular SiO tamponade in retinal detachment patients. <b>Methods and Results:</b> Vitreous fluid samples were acquired from 27 patients (27 eyes). Twelve eyes for data-independent acquisition (DIA) were divided  ...[more]

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